The series follows the story of a ten-year-old boy named George Shrinks who is only 3 inches (76 mm) tall. George lives with his musician father Harold, his artist mother Perdita, and his little brother Harold Jr. ("Junior" for short), finding adventure with them and his friends (primarily his best bud and neighbour Becky Lopez) in mundane situations - something that comes naturally as a result of his diminutive size. But through a mixture of his own ingenuity and imagination, as well as a variety of highly adaptable mini machines built by him and his dad, George proves that being tiny is no obstacle to solving problems and having fun.

George's tiny size turns mundane activities, such as working around the house or playing outside, into dramatic adventures. His primary mode of transportation is his Zoopercar, a multi-purpose miniature vehicle he built with his father that can do things like transform into a submarine, an airplane or a helicopter. George often has interesting encounters with animals who, although they don't talk, seem to be able to communicate with George throughout the series. On one occasion, he encountered a robotic alien that was his own size and helped it get back home.